Morning vaccination enhances antibody response over afternoon vaccination: A cluster-randomised trial

Abstract

OBJECTIVES Older adults are less able to produce a protective antibody response to vaccinations. One factor that contributes to this is immune ageing. Here we examined whether diurnal variations in immune responses might extend to the antibody response to vaccination. DESIGN We utilised a cluster-randomised trial design. SETTING 24 General Practices… (More)
DOI: 10.1016/j.vaccine.2016.04.032

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