Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in elderly hypertensives: a prospective study.

@article{Kario2003MorningSI,
  title={Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in elderly hypertensives: a prospective study.},
  author={Kazuomi Kario and Thomas G. Pickering and Yuji Umeda and Satoshi Hoshide and Yoko Hoshide and Masato Morinari and Mitsunobu Murata and Toshio Kuroda and Joseph E. Schwartz and Kazuyuki Shimada},
  journal={Circulation},
  year={2003},
  volume={107 10},
  pages={1401-6}
}
BACKGROUND Cardiovascular events occur most frequently in the morning hours. We prospectively studied the association between the morning blood pressure (BP) surge and stroke in elderly hypertensives. METHODS AND RESULTS We studied stroke prognosis in 519 older hypertensives in whom ambulatory BP monitoring was performed and silent cerebral infarct was assessed by brain MRI and who were followed up prospectively. The morning BP surge (MS) was calculated as follows: mean systolic BP during the… CONTINUE READING
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