Morning preprandial plasma ghrelin and catecholamine concentrations in patients with phenylketonuria and normal controls: evidence for catecholamine-mediated ghrelin regulation.

@article{Schulpis2004MorningPP,
  title={Morning preprandial plasma ghrelin and catecholamine concentrations in patients with phenylketonuria and normal controls: evidence for catecholamine-mediated ghrelin regulation.},
  author={Kleopatra H. Schulpis and Ioannis Papassotiriou and Maria Vounatsou and George Albert Karikas and Stylianos Th Tsakiris and George P. Chrousos},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2004},
  volume={89 8},
  pages={3983-7}
}
Patients with phenylketonuria (PKU) have a diet-controlled deficiency in the conversion of phenylalanine (Phe) to tyrosine (Tyr), leading to decreased production of noradrenaline, adrenaline, and dopamine. Poor diet control results in high plasma Phe and low plasma Tyr and catecholamine concentrations. Ghrelin, a recently described gastrointestinal hormone… CONTINUE READING