Morning insulin requirements. Critique of dawn and meal phenomena.

  title={Morning insulin requirements. Critique of dawn and meal phenomena.},
  author={William G. Blackard and C O Barlascini and John N. Clore and John Edwin Nestler},
  volume={38 3},
Morning insulin resistance has frequently been invoked to explain early-morning increases in both basal and breakfast-associated insulin requirements in diabetic patients. This increase in insulin requirements and plasma glucose from 0600 to 0900, when compared with midnight to 0600, has been termed the dawn phenomenon. We believe that the increased need for insulin in the morning has been misinterpreted. Data are reviewed that suggest the major perturbation overnight is a sleep-associated fall… CONTINUE READING

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