Morning hypercoagulability and hypofibrinolysis. Diurnal variations in circulating activated factor VII, prothrombin fragment F1+2, and plasmin-plasmin inhibitor complex.

@article{Kapiotis1997MorningHA,
  title={Morning hypercoagulability and hypofibrinolysis. Diurnal variations in circulating activated factor VII, prothrombin fragment F1+2, and plasmin-plasmin inhibitor complex.},
  author={Stylianos Kapiotis and Bernd Jilma and Peter Quehenberger and Katharina Ruzicka and Silvia Handler and Wolfgang Speiser},
  journal={Circulation},
  year={1997},
  volume={96 1},
  pages={19-21}
}
BACKGROUND Diurnal fluctuations of blood coagulation and fibrinolysis activity are thought to play a role in the observed circadian variation in the frequency of onset of acute cardiovascular events. In the present study, the diurnal variations in blood coagulation and fibrinolysis activity were investigated in 10 young, healthy control subjects by use of specific molecular activation markers. METHODS AND RESULTS The plasma levels of activated factor FVII (FVIIa), the active portion of the… CONTINUE READING

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