Morituri te salutant? Olfactory signal transduction and the role of phosphoinositides

@article{Elsaesser2005MorituriTS,
  title={Morituri te salutant? Olfactory signal transduction and the role of phosphoinositides},
  author={Rebecca Elsaesser and Jacques Paysan},
  journal={Journal of Neurocytology},
  year={2005},
  volume={34},
  pages={97-116}
}
During the past 150 years, researchers have investigated the cellular, physiological, and molecular mechanisms underlying the sense of smell. Based on these efforts, a conclusive model of olfactory signal transduction in the vertebrate's nose is now available, spanning from G-protein-mediated odorant receptors to ion channels, which are linked by a cyclic adenosine 3',5'-monophosphate-mediated signal transduction cascade. Here we review some historical milestones in the chronology of olfactory… Expand
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References

SHOWING 1-10 OF 241 REFERENCES
Cellular and molecular constituents of olfactory sensation in vertebrates.
  • T. Nakamura
  • Biology, Medicine
  • Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
  • 2000
TLDR
It was demonstrated that adenosine 3',5'-cyclic monophosphate (cAMP) is very likely the sole second messenger for olfactory transduction and the affinity of the cyclic nucleotide-gated channel for cAMP regulated by Ca(2+)/calmodulin is solely responsible for the adaptation of the cell. Expand
Phosphoinositide second messengers in olfaction.
  • R. C. Bruch
  • Biology, Medicine
  • Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
  • 1996
TLDR
The role of calcium as a "third messenger" that provides a mechanism for interaction between phosphoinositide second messengers and components of the cyclic AMP signaling pathway is discussed. Expand
Ultrastructural aspects of olfactory signaling.
  • B. Menco
  • Biology, Medicine
  • Chemical senses
  • 1997
TLDR
The long-standing supposition that olfactory cilia are peculiarly adapted to deal with the reception and initial transduction of odorous messages has now been verified in terms of both ultrastructural morphology and cytochemistry. Expand
Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons.
TLDR
The molecular cloning, expression, and characterization of a cDNA from rat olfactory epithelium that encodes a member of the calmodulin-dependent PDE family designated as PDE1C is reported, showing high affinity for cAMP and cGMP, which suggests an important role for it in a Ca(2+)-regulated Olfactory signal termination. Expand
Transduction mechanisms in vertebrate olfactory receptor cells.
TLDR
A comprehensive review of the biophysical and electrophysiological evidence regarding the transduction processes as well as subsequent signal processing and spike generation in ORNs is presented. Expand
Rapid activation of alternative second messenger pathways in olfactory cilia from rats by different odorants.
TLDR
In this study odor induced formation of second messengers in rat olfactory cilia was monitored in a subsecond time range using a rapid kinetic device and analysis of the kinetic parameter for the odorant induced reaction indicated that apparently two systems are operating simultaneously. Expand
Neuronal inositol 1,4,5-trisphosphate receptor localized to the plasma membrane of olfactory cilia
TLDR
These findings, taken in conjunction with electrophysiological data from other workers, are supportive of the inositol 1,4,5-trisphosphate receptor playing a novel role in regulating calcium flux at the ciliary surface membrane. Expand
Odorant-sensitive adenylate cyclase may mediate olfactory reception
TLDR
The results suggest a role for cyclic nucleotides in olfactory transduction13,20–22, and point to a molecular analogy between olfaction and visual15,16, hormone17,18 and neurotransmitter19 reception, and reveal new ways to identify and isolate Olfactory receptor proteins. Expand
Disruption of the Type III Adenylyl Cyclase Gene Leads to Peripheral and Behavioral Anosmia in Transgenic Mice
TLDR
Interestingly, electroolfactogram responses stimulated by either cAMP- or inositol 1,4,5-triphosphate- (IP3-) inducing odorants were completely ablated in AC3 mutants, despite the presence of AC2 and AC4 in olfactory cilia, indicating that AC3 and cAMP signaling are critical for olfaction-dependent behavior. Expand
Phosphatidyl‐inositide signalling proteins in a novel class of sensory cells in the mammalian olfactory epithelium
TLDR
A novel class of microvillous secondary chemosensory cells, which utilize phosphatidyl‐inositides in signal transduction, represent about 5% of all olfactory cells, and their abundance indicates that they play an important role in stimulus‐dependent functions and/or the regeneration of the Olfactory system. Expand
...
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2
3
4
5
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