Morin attenuates tau hyperphosphorylation by inhibiting GSK3β

  title={Morin attenuates tau hyperphosphorylation by inhibiting GSK3β},
  author={Eun Ji Gong and Hee Ra Park and Mi Eun Kim and Shunfu Piao and Jaewon Lee},
  journal={Neurobiology of Disease},
Alzheimer's disease (AD) is the major form of age-related dementia and is characterized by progressive cognitive impairment, the accumulation of extracellular amyloid β-peptide (Aβ), and intracellular hyperphosphorylated tau aggregates in affected brain regions. Tau hyperphosphorylation and accumulation in neurofibrillary tangles is strongly correlated with cognitive deficits, and is apparently a critical event in the dementia process because mutations in tau can cause a tangle-only form of… CONTINUE READING


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