More to come: Humoral immune responses in MS

@article{Dobson2011MoreTC,
  title={More to come: Humoral immune responses in MS},
  author={Ruth Dobson and Ute C. Meier and Gavin Giovannoni},
  journal={Journal of Neuroimmunology},
  year={2011},
  volume={240–241},
  pages={13-21}
}
Interest in the role of B-cells in multiple sclerosis (MS) pathogenesis has increased, and a number of B-cell targeted therapies are currently in clinical trials. B-cells are key mediators of the humoral immune response, with roles including antibody production and acting as antigen presenting cells. Whilst previously, the presence of B-cells within MS plaques has been thought to be secondary to T-cell dysregulation, it is now becoming clear that B-cells play an independent role in disease. In… CONTINUE READING
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