More than one‐half of a decade of experience with venlafaxine dual serotonin‐norepinephrine reuptake inhibitor

  title={More than one‐half of a decade of experience with venlafaxine dual serotonin‐norepinephrine reuptake inhibitor},
  author={Charles B. Nemeroff},
  journal={Depression and Anxiety},
  • C. Nemeroff
  • Published 2000
  • Psychology, Medicine
  • Depression and Anxiety
There are many telling reasons to assemble a special issue of Depression and Anxiety at this time on venlafaxine, the dual serotonin-norepinephrine reuptake inhibitor, that is currently approved in the United States for the treatment of major depression and generalized anxiety disorder. First, there has been increasing evidence largely compiled by Bech and his colleagues in Denmark that antidepressants that inhibit both norepinephrine and serotonin reuptake (SNRI) are more effective in severe… 
1 Citations
Ketamine and other glutamate receptor modulators for depression in adults.
Among all glutamate receptor modulators, only ketamine (administered intravenously) proved to be more efficacious than placebo, though the quality of evidence was limited by risk of bias and small sample sizes.


Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter.
Findings support the hypothesis that alterations in 5-HT neurons play a role in the pathophysiology of depression.
Role of norepinephrine in the pathophysiology and treatment of mood disorders
Role of norepinephrine in depression.
It is proposed that antidepressant drugs may enhance neurotransmission in normal noradrenergic or serotonergic neurons and, through a time-dependent but as yet undiscovered process, restore function to brain areas modulated by monoamine neurons.
Monoamine dysfunction and the pathophysiology and treatment of depression.
  • D. Charney
  • Biology, Psychology
    The Journal of clinical psychiatry
  • 1998
The results of a series of investigations confirm the importance of monoamines in the mediation of depressed mood, but also suggest that other brain neural systems may have more of a primary role than previously thought in the pathophysiology of depression.
The revised monoamine theory of depression: a modulatory role for monoamines, based on new findings from monoamine depletion experiments in humans.
The findings that relapse during treatment is specific to the type of treatment and type of depletion, that neither SD or CD produced an increase in clinical depression in healthy controls or depressed patients off medication, and that recovered patients off medications have a return of symptoms following SD, forces a major revision of the current monoamine theories of depression.
Serotonin, serotonergic receptors, selective serotonin reuptake inhibitors and sexual behaviour
Investigations are ongoing to determine whether this differential mechanism of action also applies to the other SSRIs and whether there are differences between theSSRIs with respect to their effect on sexual behaviour in rodents.
The role of noradrenaline in depression: a review.
  • B. Leonard
  • Biology
    Journal of psychopharmacology
  • 1997
Evidence is presented of a link between noradrenaline and glutamate (via the N-methyl-aspartate receptor) and receptors that may provide a basis for the future development of novel antidepressants.
Hormone responses to fenfluramine and placebo challenge in endogenous depression