More than markers: biological significance of cancer stem cell-defining molecules.

  title={More than markers: biological significance of cancer stem cell-defining molecules.},
  author={Stephen B. Keysar and Antonio J. Jimeno},
  journal={Molecular cancer therapeutics},
  volume={9 9},
Small populations within an increasing array of solid tumors, labeled cancer stem cells (CSC) or tumor-initiating cells (TIC), have the ability to differentiate, self-renew, and replicate the original tumor in vivo. To date, these cells have been distinguished from the bulk-tumor population by the expression pattern of cell-surface proteins (e.g., CD24, CD44, CD133) and cellular activities, such as the efflux of Hoechst dye or aldehyde dehydrogenase activity. Recent data have shown that these… CONTINUE READING
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