More than folding: localized functions of cytosolic chaperones.

  title={More than folding: localized functions of cytosolic chaperones.},
  author={Jason C Young and Jos{\'e} M. Barral and F Ulrich Hartl},
  journal={Trends in biochemical sciences},
  volume={28 10},
Compared with other chaperone systems, heat shock proteins Hsp70 and Hsp90 interact with a larger variety of co-chaperone proteins that regulate their activity or aid in the folding of specific substrate proteins. Although many co-chaperones are soluble cytosolic proteins, co-chaperone domains are also found in modular adaptor proteins, which are often localized to intracellular membranes or elements of the cytoskeleton. These specialized co-chaperones include auxilin, cysteine string protein… CONTINUE READING


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