More reliable outcome measures can reduce sample size requirements.

Abstract

In the design of a clinical trial, considerations of statistical power primarily involve the evaluation of prospective sample sizes. Another strategy for increasing statistical power that is rarely used focuses on the selection of the outcome measure. When an outcome measure is selected, its reliability and validity must be carefully evaluated. Here the… (More)

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Cite this paper

@article{Leon1995MoreRO, title={More reliable outcome measures can reduce sample size requirements.}, author={A. C. Leon and Peter M. Marzuk and Laura Portera}, journal={Archives of general psychiatry}, year={1995}, volume={52 10}, pages={867-71} }