More hippocampal neurons in adult mice living in an enriched environment

@article{Kempermann1997MoreHN,
  title={More hippocampal neurons in adult mice living in an enriched environment},
  author={Gerd Kempermann and Hans Georg Kuhn and Fred H. Gage},
  journal={Nature},
  year={1997},
  volume={386},
  pages={493-495}
}
Neurogenesis occurs in the dentate gyrus of the hippocampus throughout the life of a rodent1–4, but the function of these new neurons and the mechanisms that regulate their birth are unknown. Here we show that significantly more new neurons exist in the dentate gyrus of mice exposed to an enriched environment compared with littermates housed in standard cages. We also show, using unbiased stereology, that the enriched mice have a larger hippocampal granule cell layer and 15 per cent more… 

Neurogenesis in the adult hippocampus

Recent findings regarding the developmental steps involved in adult hippocampal neurogenesis are summarized and the possible functional roles that new hippocampal neurons might play are summarized.

Functional neurogenesis in the adult hippocampus

It is reported that newly generated cells in the adult mouse hippocampus have neuronal morphology and can display passive membrane properties, action potentials and functional synaptic inputs similar to those found in mature dentate granule cells.

Development of neural circuits in the adult hippocampus.

Neurogenesis in the adult hippocampus

The dentate gyrus (DG) contains one of the few neuronal populations in the mammalian brain that are generated throughout life and some of the methods most commonly used for studying these processes.

Learning enhances adult neurogenesis in the hippocampal formation

It is reported that the number of adult-generated neurons doubles in the rat dentate gyrus in response to training on associative learning tasks that require the hippocampus, which indicates that adult- generated hippocampal neurons are specifically affected by, and potentially involved in, associative memory formation.

Neurogenesis in the adult human hippocampus

It is demonstrated that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans, indicating that the human hippocampus retains its ability to generate neurons throughout life.

Regulation of hippocampal neurogenesis in adulthood

Integration of New Neurons into the Adult Hippocampus

The process of integration of newborn neurons into the neural circuitry of the hippocampus in adult rodents is described and how hippocampal neurogenesis is regulated by the neural network activity is discussed.

Differential neurogenesis in the adult rat dentate gyrus: an identifiable zone that consistently lacks neurogenesis

An area located at the anterior pole of the dentate gyrus that consistently lacks neurogenesis is described, and it is proposed that this region may provide a valuable model system to discern the factors that regulate the process of Neurogenesis.
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