More frequent beta-catenin exon 3 mutations in gallbladder adenomas than in carcinomas indicate different lineages.

@article{Yanagisawa2001MoreFB,
  title={More frequent beta-catenin exon 3 mutations in gallbladder adenomas than in carcinomas indicate different lineages.},
  author={Naotake Yanagisawa and Tetuo Mikami and Makoto Saegusa and Isao Okayasu},
  journal={Cancer research},
  year={2001},
  volume={61 1},
  pages={19-22}
}
To clarify the contribution of beta-catenin, which is related to cell adhesion and intranuclear transcription, to gallbladder carcinogenesis, we investigated its expression using immunohistochemistry, and beta-catenin exon 3 mutations by DNA direct sequencing, in 18 gallbladder adenomas and 82 adenocarcinomas. Membranous expression was significantly lower… CONTINUE READING