More frequent Lewy bodies but less frequent Alzheimer-type lesions in multiple system atrophy as compared to age-matched control brains

@article{Jellinger2007MoreFL,
  title={More frequent Lewy bodies but less frequent Alzheimer-type lesions in multiple system atrophy as compared to age-matched control brains},
  author={Kurt A. Jellinger},
  journal={Acta Neuropathologica},
  year={2007},
  volume={114},
  pages={299-303}
}
  • K. Jellinger
  • Published 3 May 2007
  • Medicine
  • Acta Neuropathologica
Multiple system atrophy (MSA), a largely sporadic adultonset progressive synucleinopathy, is divided into two clinicopathologic subtypes: MSA-P [striatonigral degeneration (SND) with predominant Parkinsonian features] and MSAC [olivopontocerebellar atrophy (OPCA) with predominant cerebellar ataxia], whereas autonomic dysfunction common to all forms of MSA and referred to previously as ShyDrager syndrome (SDS), has been discouraged in the new consensus criteria [6]. Neuropathology, in addition… Expand
Frequent globular neuronal cytoplasmic inclusions in the medial temporal region as a possible characteristic feature in multiple system atrophy with dementia
TLDR
Analysis of autopsy‐proven MSA cases with and without dementia suggests that frequent G‐NCIs in the medial temporal region, and particularly the subiculum, is one of the important pathological findings of MSA‐D, even when a case with M SA‐D reveals no significant cerebral atrophy. Expand
Multiple System Atrophy: An Oligodendroglioneural Synucleinopathy1
  • K. Jellinger
  • Medicine, Psychology
  • Journal of Alzheimer's disease : JAD
  • 2018
TLDR
Multidisciplinary research to elucidate the genetic and molecular background of the deleterious cycle of noxious processes, to develop reliable biomarkers and targets for effective treatment of this hitherto incurable disorder is urgently needed. Expand
Recent advances in neuropathology, biomarkers and therapeutic approach of multiple system atrophy
  • S. Koga, D. Dickson
  • Psychology, Medicine
  • Journal of Neurology, Neurosurgery, and Psychiatry
  • 2017
TLDR
Recent advances in neuropathology of MSA are described from a review of the literature and from information derived from review of nearly 200 definite MSA cases in the Mayo Clinic Brain Bank. Expand
Neuropathology of multiple system atrophy: New thoughts about pathogenesis
  • K. Jellinger
  • Medicine, Biology
  • Movement disorders : official journal of the Movement Disorder Society
  • 2014
TLDR
Histological core feature are glial cytoplasmic inclusions in all types of oligodendroglia that contain aggregates of misfolded α‐Synuclein (α‐Syn), which are suggested finally to lead to a system‐specific pattern of neurodegeneration. Expand
Expanding the spectrum of neuronal pathology in multiple system atrophy.
TLDR
The identification of widespread neuronal inclusions in the majority of patients, not only in typical disease-associated regions, but also within anterior cingulate cortex, amygdala, entorhinal cortex, basal forebrain and hypothalamus, suggests that in addition to glial inclusions, neuronal pathology plays an important role in the developmental and progression of multiple system atrophy. Expand
Unusual tau in MSA
  • K. Jellinger
  • Medicine
  • Neuropathology : official journal of the Japanese Society of Neuropathology
  • 2012
TLDR
A recent clinico-pathological study of seven cases of multiple system atrophy revealed unusual tau-positive cytoplasmic inclusions in astroglia, predominantly in the putamen, internal capsule and pontine basis, suggesting that tau may be related to a neurodegenerative pathway different from that induced by aSyn. Expand
Long duration of multiple system atrophy
  • K. Jellinger
  • Medicine
  • Neuropathology : official journal of the Japanese Society of Neuropathology
  • 2012
TLDR
A recent clinico-pathological study of a case of multiple system atrophy in a woman aged 82 years with prolonged clinical course of 18 years, extensive distribution of p-aSyn+ glial cytoplasmic inclusions in the sensory cortex and the limbic system being rather unusual is suggested. Expand
Dementia in multiple system atrophy: does it exist?
Multiple system atrophy (MSA) is a fatal a-synucleinopathy characterized clinically by progressive autonomic failure, parkinsonism – often poorly responsive to levodopa – and cerebellar ataxia in anyExpand
Etiology, Pathology, and Pathogenesis
TLDR
The correlation of subregional glial cytoplasmic inclusion (GCI) density and neuronal loss suggests that α-synuclein aggregation is tightly linked to selective neurodegeneration in MSA. Expand
Neuropathology and pathophysiology of multiple system atrophy
  • K. Jellinger
  • Medicine
  • Neuropathology and applied neurobiology
  • 2012
TLDR
Although the proposed morphological grading correlated well with initial symptoms and clinical key features of both MSA subtypes, further prospective studies are required to validate the clinical utility of the proposed MSA grading scales. Expand
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