More Aroused, Less Fatigued: Fatty Acid Amide Hydrolase Gene Polymorphisms Influence Acute Response to Amphetamine

@article{Dlugos2010MoreAL,
  title={More Aroused, Less Fatigued: Fatty Acid Amide Hydrolase Gene Polymorphisms Influence Acute Response to Amphetamine},
  author={Andrea M. Dlugos and Ajna Hamidovic and Colin Hodgkinson and David Goldman and Abraham A Palmer and Harriet de Wit},
  journal={Neuropsychopharmacology},
  year={2010},
  volume={35},
  pages={613-622}
}
Amphetamine is a stimulant drug that enhances attention and feelings of alertness. Amphetamine's effects are known to be modulated by endogenous cannabinoids, which are degraded by the enzyme fatty acid amide hydrolase (FAAH). In this study we investigated inter-individual differences in mood response to amphetamine in relation to four polymorphisms in the FAAH gene, including the FAAH missense variant rs324420C → A (Pro129Thr), which was previously found to be associated with street drug use… CONTINUE READING
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