Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting*

@article{Koch2006MorbidityAM,
  title={Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting*},
  author={Colleen Gorman Koch and Liang Li and Andra Ibrahim Duncan and Tomislav Mihaljevic and Delos M. Cosgrove and Floyd D. Loop and Norman J. Starr and Eugene H. Blackstone},
  journal={Critical Care Medicine},
  year={2006},
  volume={34},
  pages={1608-1616}
}
Objective:Our objective was to quantify incremental risk associated with transfusion of packed red blood cells and other blood components on morbidity after coronary artery bypass grafting. Design:The study design was an observational cohort study. Setting:This investigation took place at a large tertiary care referral center. Patients:A total of 11,963 patients who underwent isolated coronary artery bypass from January 1, 1995, through July 1, 2002. Interventions:None. Measurements and Main… 
Did blood transfusion increase mortality in patients with diabetes undergoing isolated coronary artery bypass graft surgery? A propensity score-matched analysis of 816 patients
TLDR
Clinical outcomes of blood transfusion in patients with diabetes mellitus undergoing isolated on-pump coronary artery bypass grafting showed that clinical outcomes were more severely affected by blood transfusions.
Clinical and economic outcomes associated with blood transfusions among elderly Americans following coronary artery bypass graft surgery requiring cardiopulmonary bypass.
TLDR
Blood transfusion during hospitalisation for coronary artery bypass graft requiring cardiopulmonary bypass was significantly associated with increased long-term post-operative morbidity, mortality, and overall healthcare costs.
Association of red blood cell transfusion and short- and longer-term mortality after coronary artery bypass graft surgery.
TLDR
Patients undergoing CABG surgery and receiving <6 U of PRBC did not have statistically increased risk for in-hospital mortality and up to 2 years postoperatively, and cumulatively there was no statistical difference between the transfused and nontransfused groups at 4 years.
Does Blood Transfusion Affect Intermediate Survival after Coronary Artery Bypass Surgery?
TLDR
Transfusion of any blood product is associated with a significant risk of all-cause and cardiac mortality after coronary artery bypass surgery, and perioperative use of fresh frozen plasma or Octaplas seems to be the main determinant of mortality.
Transfusion of Red Blood Cells, Fresh Frozen Plasma, or Platelets Is Associated With Mortality and Infection After Cardiac Surgery in a Dose-Dependent Manner
TLDR
Transfusion of red blood cells, fresh frozen plasma, or platelets is an independent risk factor of mortality and infection, and combination of the 3 blood products is associated with adverse outcomes after cardiac surgery in a dose-dependent manner.
Mortality risk is dose-dependent on the number of packed red blood cell transfused after coronary artery bypass graft
TLDR
The mortality risk is directly proportional to the number of packed red blood cells transfused in coronary artery bypass graft, and the greater the amount of allogeneic blood transfused the more the risk of mortality.
...
...

References

SHOWING 1-10 OF 62 REFERENCES
Factors affecting transfusion of fresh frozen plasma, platelets, and red blood cells during elective coronary artery bypass graft surgery.
CONTEXT The ability to predict the use of blood components during surgery will improve the blood bank's ability to provide efficient service. OBJECTIVE Develop prediction models using preoperative
Variability in Transfusion Practice for Coronary Artery Bypass Surgery Persists Despite National Consensus Guidelines: A 24‐Institution Study
TLDR
Significant variability in institutional transfusion practice was observed for allogeneic packed red blood cells (PRBCs) and hemostatic blood components and for patients at institutions with liberal rather than conservative transfusions practice.
Determinants of red cell, platelet, plasma, and cryoprecipitate transfusions during coronary artery bypass graft surgery: the Collaborative Hospital Transfusion Study
TLDR
The classification of coronary artery bypass graft patients on the basis of attributes known preoperatively and by conduits used yields subsets of patients with distinctly different transfusion requirements and in‐ hospital outcomes.
Variability in transfusion practice for coronary artery bypass surgery persists despite national consensus guidelines: a 24-institution study. Institutions of the Multicenter Study of Perioperative Ischemia Research Group.
TLDR
A more rational and conservative approach to transfusion practice at the institutional level is warranted as institutions continue to vary significantly in their transfusion practices for CABG surgery.
Predictors of homologous blood transfusion for patients undergoing open heart surgery.
TLDR
There is normally no need for blood transfusion in (2/3) of the patients in cardiac surgery according to this study's results, and it was obvious that some patient variables can be used predict the risk for perioperative transfusion.
Blood Use in Patients Undergoing Coronary Artery Bypass Surgery: Impact Of Cardiopulmonary Bypass Pump, Hematocrit, Gender, Age, and Body Weight
TLDR
The impact of CPB, off-pump status, preoperative hematocrit <35%, gender, age ≥65 yr, and weight ≤83 kilograms using median values as cut points, on blood use was examined using logistic regression models.
Effect of blood transfusion on long-term survival after cardiac operation.
Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes.
TLDR
Blood transfusion in the setting of acute coronary syndromes is associated with higher mortality, and this relationship persists after adjustment for other predictive factors and timing of events.
...
...