Morbidity and mortality in chronically transfused subjects with thalassemia and sickle cell disease: A report from the multi-center study of iron overload.

@article{Fung2007MorbidityAM,
  title={Morbidity and mortality in chronically transfused subjects with thalassemia and sickle cell disease: A report from the multi-center study of iron overload.},
  author={Ellen B. Fung and Paul R. Harmatz and Meredith J Milet and Samir K Ballas and L Cirne de Castro and Ward Hagar and William H. Owen and Nancy A Olivieri and Kim Smith-Whitley and Deepika S Darbari and Winfred C. Wang and Elliott Vichinsky},
  journal={American journal of hematology},
  year={2007},
  volume={82 4},
  pages={
          255-65
        }
}
A natural history study was conducted in 142 Thalassemic (Thal), 199 transfused Sickle Cell Disease (Tx-SCD, n = 199), and 64 non-Tx-SCD subjects to describe the frequency of iron-related morbidity and mortality. Subjects recruited from 31 centers in the US, Canada or the UK were similar with respect to age (overall: 25 +/- 11 years, mean +/- SD) and gender (52% female). We found that Tx-SCD subjects were hospitalized more frequently compared with Thal or non-Tx-SCD (P < 0.001). Among those… CONTINUE READING
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