Moraxella catarrhalis is internalized in respiratory epithelial cells by a trigger-like mechanism and initiates a TLR2- and partly NOD1-dependent inflammatory immune response.

@article{Slevogt2007MoraxellaCI,
  title={Moraxella catarrhalis is internalized in respiratory epithelial cells by a trigger-like mechanism and initiates a TLR2- and partly NOD1-dependent inflammatory immune response.},
  author={Hortense Slevogt and Joachim Seybold and Krishna Tiwari and Andreas Hocke and Carola Jonatat and Solveig Dietel and Stefan Hippenstiel and Bernhard B Singer and Sebastian Bachmann and Norbert Suttorp and Bastian Opitz},
  journal={Cellular microbiology},
  year={2007},
  volume={9 3},
  pages={
          694-707
        }
}
  • Hortense Slevogt, Joachim Seybold, +8 authors Bastian Opitz
  • Published in Cellular microbiology 2007
  • Biology, Medicine
  • Moraxella catarrhalis is an important pathogen in patients with chronic obstructive lung disease (COPD). While M. catarrhalis has been categorized as an extracellular bacterium so far, the potential to invade human respiratory epithelium has not yet been explored. Our results obtained by electron and confocal microscopy demonstrated a considerable potential of M. catarrhalis to invade bronchial epithelial (BEAS-2B) cells, type II pneumocytes (A549) and primary small airway epithelial cells… CONTINUE READING

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