• Biology
  • Published 2000

Moraxella catarrhalis Is a Factor in Resistance to Bactericidal Activity Mediated by Normal Human Serum

@inproceedings{Zaleski2000MoraxellaCI,
  title={Moraxella catarrhalis Is a Factor in Resistance to Bactericidal Activity Mediated by Normal Human Serum},
  author={Anthony Zaleski and N. Karoline Scheffler and Peter Densen and Frank K. N. Lee and Anthony A. Campagnari and Bradford W. Gibson and Michael A. Apicella},
  year={2000}
}
Moraxella catarrhalis is a respiratory pathogen responsible for acute bacterial otitis media in children and exacerbation of chronic bronchitis in adults. M. catarrhalis strains are frequently resistant to the bactericidal activity of normal human serum. In order to determine if the lipooligosaccharide (LOS) of M. catarrhalis has a role in serum resistance, the UDP-glucose-4-epimerase (galE) gene was identified, cloned, and sequenced and a deletion/insertion mutation was introduced into M… CONTINUE READING

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