Moonlighting by different stressors: crystal structure of the chaperone species of a 2-Cys peroxiredoxin.

@article{Saccoccia2012MoonlightingBD,
  title={Moonlighting by different stressors: crystal structure of the chaperone species of a 2-Cys peroxiredoxin.},
  author={Fulvio Saccoccia and Patrizio Di Micco and Giovanna Boumis and Maurizio Brunori and Ilias Koutris and Adriana Erica Miele and Veronica Morea and Palita Sriratana and David L. Williams and Andrea Bellelli and Francesco Angelucci},
  journal={Structure},
  year={2012},
  volume={20 3},
  pages={
          429-39
        }
}
2-Cys peroxiredoxins (Prxs) play two different roles depending on the physiological status of the cell. They are thioredoxin-dependent peroxidases under low oxidative stress and ATP-independent chaperones upon exposure to high peroxide concentrations. These alternative functions have been associated with changes in the oligomerization state from low-(LMW) to high-molecular-weight (HMW) species. Here we present the structures of Schistosoma mansoni PrxI in both states: the LMW decamer and the… CONTINUE READING
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