Moonlighting at replication forks - a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51.

@article{Kolinjivadi2017MoonlightingAR,
  title={Moonlighting at replication forks - a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51.},
  author={Arun Mouli Kolinjivadi and Vincenzo Sannino and Anna de Antoni and Herv{\'e} T{\'e}cher and Giorgio Baldi and Vincenzo Costanzo},
  journal={FEBS letters},
  year={2017},
  volume={591 8},
  pages={1083-1100}
}
Coordination between DNA replication and DNA repair ensures maintenance of genome integrity, which is lost in cancer cells. Emerging evidence has linked homologous recombination (HR) proteins RAD51, BRCA1 and BRCA2 to the stability of nascent DNA. This function appears to be distinct from double-strand break (DSB) repair and is in part due to the prevention of MRE11-mediated degradation of nascent DNA at stalled forks. The role of RAD51 in fork protection resembles the activity described for… CONTINUE READING
Highly Cited
This paper has 39 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS
17 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…