Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved.

@article{Khandelwal2007MoonlightingAO,
  title={Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved.},
  author={Abha Khandelwal and Dilip Chandu and Catherine M. Roe and Raphael Kopan and Ralph S. Quatrano},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 33},
  pages={13337-42}
}
Presenilins (PS) provide the catalytic activity for gamma-secretase, which cleaves physiologically relevant substrates including Notch, ErbB4, and APP. Recent genetic studies indicated that the contribution of PS1 to mouse development includes gamma-secretase-independent functions that cannot be easily explained by any of the demonstrated or hypothesized functions of this protein. To begin a nonbiased analysis of PS1 activity unencumbered by the dominant effect stemming from loss of Notch… CONTINUE READING
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