Mood disorders and dysfunction of the hypothalamic-pituitary-adrenal axis in multiple sclerosis: association with cerebral inflammation.

@article{Fassbender1998MoodDA,
  title={Mood disorders and dysfunction of the hypothalamic-pituitary-adrenal axis in multiple sclerosis: association with cerebral inflammation.},
  author={Klaus Fassbender and Reinhold Schmidt and Rotraut M{\"o}\ssner and Udo Kischka and J Kuehnen and Antoine Schwartz and M. Hennerici},
  journal={Archives of neurology},
  year={1998},
  volume={55 1},
  pages={66-72}
}
OBJECTIVE To investigate the association between affective and neuroendocrine abnormalities, commonly observed in multiple sclerosis, with inflammatory disease activity. DESIGN Cross-sectional design. Twenty-three patients with definite relapsing-remitting multiple sclerosis and age- and sex-matched control subjects were investigated. Depression and anxiety were assessed using structured interviews, self-report measures, and Diagnostic and Statistical Manual of Mental Disorders, Third Edition… CONTINUE READING