Mood and gut feelings

  title={Mood and gut feelings},
  author={Paul Forsythe and Nobuyuki Sudo and Timothy G. Dinan and Valerie H. Taylor and John Bienenstock},
  journal={Brain, Behavior, and Immunity},

Can microbiology affect psychiatry? A link between gut microbiota and psychiatric disorders.

There is a link between the composition of gut microbiota and mental disorders in animals ( response to depression and chronic stress) and this subject requires further examination, especially taking into consideration potential therapeutic options.

Clinical effects of probiotics on the functioning of the gut-brain axis in children

This review is devoted to the new interesting area that correlates the gut microbiota with nervous system diseases and its possible treatment with psychobiotics.

Commensal communication to the brain: pathways and behavioral consequences

This brief paper highlights some of the recent findings which promote the functional importance of this communication between gut commensals and the enteric and central nervous systems and was part of a lecture given recently at a meeting at the Karolinska Institutet on ‘The Gut and The Brain’.

Microbiota in Neuropsychiatry, Part 3: Psychobiotics as Modulators of Mood Disorders

Research has emerged that suggests potential therapeutic approaches to modulate and stabilize the gut microbiota and to restore its healthy composition from dysbiotic states in various conditions, such as mood disorders.

The impact of microbiota on brain and behavior: mechanisms & therapeutic potential.

The concept of a microbiome-brain-gut axis is emerging, suggesting microbiota-modulating strategies may be a tractable therapeutic approach for developing novel treatments for CNS disorders.

Microbiota and the gut-brain axis.

In the future, the composition, diversity, and function of specific probiotics, coupled with similar, more detailed knowledge about gut microbiota, will potentially help in developing more effective diet- and drug-based therapies.

Voices from within: gut microbes and the CNS

Understanding of the mechanisms underlying microbiome–gut–brain communication will provide new insight into the symbiotic relationship between gut microbiota and their mammalian hosts and help to identify the potential for microbial-based therapeutic strategies to aid in the treatment of mood disorders.

The microbiome: stress, health and disease

The concept of a microbiome–brain–gut axis is emerging which suggests that modulation of the gut microflora may be a tractable strategy for developing novel therapeutics for complex stress-related CNS disorders where there is a huge unmet medical need.


It is intriguing to speculate that the regular antibiotic consumption early in life may affect brain development via the microbiota gut brain axis.

The role of microbiome in central nervous system disorders




The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease.

Gaining a better understanding of the relationship between behavior and the microbiota could provide insight into the pathogenesis of functional and inflammatory bowel disorders.

The human gut microbiome: Implications for future health care

This review summarizes the research that is defining the understanding of the intestinal microbiome and highlights future areas of research in gastroenterology and human health in which the intestine microbiome will play a significant role.

Development of the Human Infant Intestinal Microbiota

A microarray is designed to detect and quantitate the small subunit ribosomal RNA (SSU rRNA) gene sequences of most currently recognized species and taxonomic groups of bacteria and suggested that incidental environmental exposures play a major role in determining the distinctive characteristics of the microbial community in each baby.

Unraveling the Molecular Details Involved in the Intimate Link between the Immune and Neuroendocrine Systems

The molecular details (including the emerging role of Toll-like receptors during inflammation) underlying the influence of circulating inflammatory molecules on the cerebral tissue are described, focusing on their contribution in the synthesis and action PGE2 in the brain.

The gut microbiota as an environmental factor that regulates fat storage.

It is found that conventionalization of adult germ-free (GF) C57BL/6 mice with a normal microbiota harvested from the distal intestine of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.

A microbial symbiosis factor prevents intestinal inflammatory disease

It is reported here that the prominent human symbiont Bacteroides fragilis protects animals from experimental colitis induced by Helicobacter hepaticus and that molecules of the bacterial microbiota can mediate the critical balance between health and disease.

From inflammation to sickness and depression: when the immune system subjugates the brain

In response to a peripheral infection, innate immune cells produce pro-inflammatory cytokines that act on the brain to cause sickness behaviour, which can lead to an exacerbation of sickness and the development of symptoms of depression in vulnerable individuals.

The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.