Mood and cognitive side effects of interferon-alpha therapy.

  title={Mood and cognitive side effects of interferon-alpha therapy.},
  author={Alan D. Valentine and Christina A. Meyers and Mitchel A. Kling and Elliott Richelson and P{\'e}ter Hauser},
  journal={Seminars in oncology},
  volume={25 1 Suppl 1},
The central nervous system side effects associated with interferon-alpha (IFN-alpha) therapy, including depression and cognitive changes, can compromise otherwise effective immunotherapy. The term "depression" has multiple meanings ranging from a feeling of sadness to a neuropsychiatric disorder with defined diagnostic criteria. A syndrome of mood disturbance with memory impairment, cognitive slowing, and impaired executive function is common with IFN-alpha therapy and is consistent with mild… CONTINUE READING
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