Monthly corticosteroids decrease neutralizing antibodies to IFNβ1b: a randomized trial in multiple sclerosis

@article{Pozzilli2002MonthlyCD,
  title={Monthly corticosteroids decrease neutralizing antibodies to IFNβ1b: a randomized trial in multiple sclerosis},
  author={Carlo Pozzilli and Giovanni Antonini and Francesca R Bagnato and Caterina Mainero and Valentina Tomassini and Emanuela Onesti and Roberta Fantozzi and Simona Galgani and Patrizio Pasqualetti and Enrico Millefiorini and Maria Spadaro and Frank Dahlke and Claudio Gasperini},
  journal={Journal of Neurology},
  year={2002},
  volume={249},
  pages={50-56}
}
Neutralizing antibodies (NAB) to interferon beta (IFNβ) occur in some multiple sclerosis (MS) patients, particularly during the first year of treatment. The presence of NAB may be associated with an attenuation of the therapeutic effect. The aim of this study was to compare the frequency of NAB occurrence in patients treated with IFNβ-1 b with that in patients treated with IFNβ-1 b combined with monthly pulses of intravenous methylprednisolone (MP). One hundred and sixty-one patients with… CONTINUE READING