Montelukast regulates eosinophil protease activity through a leukotriene-independent mechanism.

  title={Montelukast regulates eosinophil protease activity through a leukotriene-independent mechanism.},
  author={Anick Langlois and Claudine Ferland and Guy M. Tremblay and Michel Laviolette},
  journal={The Journal of allergy and clinical immunology},
  volume={118 1},
BACKGROUND Migration of eosinophils into bronchial mucosa requires proteolysis. Montelukast, a cysteinyl leukotriene (CysLT) 1 receptor antagonist used in asthma treatment, decreases eosinophil infiltration into the asthmatic airways, suggesting that CysLTs modulate eosinophil protease activity. OBJECTIVE We sought to determine whether CysLTs and montelukast regulate eosinophil protease activity. METHODS Purified blood eosinophils were treated with or without montelukast; MK-0591, a 5… CONTINUE READING


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