Montelukast potentiates the protective effect of rofecoxib against kainic acid-induced cognitive dysfunction in rats.

@article{Kumar2012MontelukastPT,
  title={Montelukast potentiates the protective effect of rofecoxib against kainic acid-induced cognitive dysfunction in rats.},
  author={Anil Kumar and Atish Kumar Prakash and Deeksha Pahwa and Jitendriya Mishra},
  journal={Pharmacology, biochemistry, and behavior},
  year={2012},
  volume={103 1},
  pages={43-52}
}
There is an evolving consensus that mild cognitive impairment (MCI) serves as a prodrome to Alzheimer's disease. Antioxidants and COX-2 (cyclo-oxygenase-2) inhibitors have also been reported to have beneficial effects against conditions of memory impairment. Newer drugs like cysteinyl leukotriene inhibitors have shown neuroprotective effect in animal models of ischemia. Thus, the present study purports to explore the potential role of montelukast (a cysteinyl leukotriene inhibitor) in concert… CONTINUE READING