Montelukast is as effective as penicillin in treatment of acute otitis media: An experimental rat study

@inproceedings{Uar2013MontelukastIA,
  title={Montelukast is as effective as penicillin in treatment of acute otitis media: An experimental rat study},
  author={Seçil Uçar and T. Kh. Huseynov and Melahat Çoban and S{\"u}len Sarıoğlu and B{\"u}lent Şerbetçioğlu and Arzu Didem Yalçın},
  booktitle={Medical science monitor basic research},
  year={2013}
}
BACKGROUND Leukotrienes are the major factors in the formation of edema and mucus, as well as development of tuba Eustachii dysfunction in acute otitis media. We developed an experimental acute suppurative otitis media model and compared the responses of rats to penicillin and combinations of leukotriene antagonist with respect to histopathological observations conducted in early and late phases. MATERIAL AND METHODS A total of 83 ears from 56 Wistar rats were used in this study. Pneumococcus… CONTINUE READING

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