Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice.

@article{Yu2005MontelukastAC,
  title={Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice.},
  author={Guo-liang Yu and Er-qing Wei and Shi-Hong Zhang and Hui-ming Xu and Li-sheng Chu and Wei-ping Zhang and Qi Zhang and Zhong Chen and Ru-Huan Mei and Meng-hui Zhao},
  journal={Pharmacology},
  year={2005},
  volume={73 1},
  pages={31-40}
}
Our previous studies showed that cysteinyl leukotriene receptor-1 (CysLT1) antagonist pranlukast has a neuroprotective effect on cerebral ischemia in rats and mice. However, whether the neuroprotective effect of pranlukast is its special action or a common action of CysLT1 receptor antagonists remains to be clarified. This study was performed to determine whether montelukast, another CysLT1 receptor antagonist, has the neuroprotective effect on focal cerebral ischemia in mice, and to observe… CONTINUE READING
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