Monte Carlo tests for associations between disease and alleles at highly polymorphic loci.

@article{Sham1995MonteCT,
  title={Monte Carlo tests for associations between disease and alleles at highly polymorphic loci.},
  author={Pak Chung Sham and David Curtis},
  journal={Annals of human genetics},
  year={1995},
  volume={59 1},
  pages={
          97-105
        }
}
In an association analysis comparing cases and controls with respect to allele frequencies at a highly polymorphic locus, a potential problem is that the conventional chi-squared test may not be valid for a large, sparse contingency table. However, reliance on statistics with known asymptotic distribution is now unnecessary, as Monte Carlo simulations can be performed to estimate the significance level of any test statistic. We have implemented a Monte Carlo method for four 'chi-squared' test… CONTINUE READING

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