Monte Carlo modeling of single-molecule cytoplasmic dynein.

  title={Monte Carlo modeling of single-molecule cytoplasmic dynein.},
  author={Manoranjan P Singh and Roop Mallik and Steven P. Gross and Clare C. Yu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 34},
Molecular motors are responsible for active transport and organization in the cell, underlying an enormous number of crucial biological processes. Dynein is more complicated in its structure and function than other motors. Recent experiments have found that, unlike other motors, dynein can take different size steps along microtubules depending on load and ATP concentration. We use Monte Carlo simulations to model the molecular motor function of cytoplasmic dynein at the single-molecule level… CONTINUE READING
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