Monozygotic twins of discordant sex both with 45,X/46,X,idic(Y) mosaicism.

  title={Monozygotic twins of discordant sex both with 45,X/46,X,idic(Y) mosaicism.},
  author={Atsuko Fujimoto and W D Boelter and Robert S. Sparkes and Ming Lin Lin and K Battersby},
  journal={American journal of medical genetics},
  volume={41 2},
A female twin with short stature, unusual facial appearance, widely spaced nipples, and coarctation of the aorta was found to have a peripheral blood lymphocyte karyotype of 45,X(43%)/46,X,idic(Y)(p11). Her twin brother, also short with similar facial appearance, had the same mosaicism (40% 45,X). Cultured skin fibroblast studies showed discrepant karyotypes of 45,X (100%) in the girl and 45,X (78%)/46,X,idic(Y)(p11) in the boy. The mother and the father had normal chromosomes. Comparison of 27… CONTINUE READING
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