Monozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin

@inproceedings{Byrne2013MonozygoticTA,
  title={Monozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin},
  author={Enda M Byrne and Tania Carrillo-Roa and Anjali K. Henders and L Bowdler and Allan F. McRae and A Christopher Heath and Nicholas G. Martin and G. W. Montgomery and Lutz Krause and Naomi R Wray},
  booktitle={Translational Psychiatry},
  year={2013}
}
Our understanding of major depressive disorder (MDD) has focused on the influence of genetic variation and environmental risk factors. Growing evidence suggests the additional role of epigenetic mechanisms influencing susceptibility for complex traits. DNA sequence within discordant monozygotic twin (MZT) pairs is virtually identical; thus, they represent a powerful design for studying the contribution of epigenetic factors to disease liability. The aim of this study was to investigate whether… CONTINUE READING
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