Monovalent and polymeric 5N-thioacetamido sialosides as tightly-bound receptor analogs of influenza viruses.

@article{Tuzikov1997MonovalentAP,
  title={Monovalent and polymeric 5N-thioacetamido sialosides as tightly-bound receptor analogs of influenza viruses.},
  author={Alexander B. Tuzikov and Nargiz E. Byramova and Nicolai V. Bovin and Alexandra S. Gambaryan and Mikhail Matrosovich},
  journal={Antiviral research},
  year={1997},
  volume={33 2},
  pages={129-34}
}
A possible approach to the development of synthetic inhibitors of influenza virus attachment to host cells is based on the anchoring of the minimum receptor determinant of influenza virus, sialic acid, to a polymeric carrier. In this study, the effect of substitution of oxygen by sulphur in the 5N-acetyl moiety of sialic acid on the binding of monovalent and polymeric sialosides by A and B influenza virus strains was investigated. The polymeric inhibitor with pendant 5N-thioacetylneuraminic… CONTINUE READING

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