Monovalent Fab' immunoglobulin fragments from endemic pemphigus foliaceus autoantibodies reproduce the human disease in neonatal Balb/c mice.

@article{Rock1990MonovalentFI,
  title={Monovalent Fab' immunoglobulin fragments from endemic pemphigus foliaceus autoantibodies reproduce the human disease in neonatal Balb/c mice.},
  author={Benjamin Rock and R. S. Labib and Luis A Diaz},
  journal={The Journal of clinical investigation},
  year={1990},
  volume={85 1},
  pages={296-9}
}
Fogo selvagem (FS) is an autoimmune disease caused by IgG autoantibodies to desmoglein I (DG-I), a desmosomal glycoprotein. We have previously shown that the autoantibodies in these patients are pathogenic and restricted mainly to the IgG4 subclass. The purpose of this study was to determine if the Fc domain or the valence of FS autoantibodies were relevant in the induction of epidermal disease in neonatal mice. IgG4 was prepared from sera of FS patients by anion exchange chromatography, and… CONTINUE READING

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Restricted heterogeneity of IgG subclasses in fogo selvagem ( endemic pemphigus foliaceus )

  • C. R. Martins, E. A. Rivitti, A. N. Theofilopoulos, L. A. Diaz
  • N . Engl . J . Med .
  • 1989

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