Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function.

  title={Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function.},
  author={K. Maedler and J. Oberholzer and P. Bucher and G. Spinas and M. Donath},
  volume={52 3},
  • K. Maedler, J. Oberholzer, +2 authors M. Donath
  • Published 2003
  • Biology, Medicine
  • Diabetes
  • Glucotoxicity and lipotoxicity contribute to the impaired beta-cell function observed in type 2 diabetes. Here we examine the effect of saturated and monounsaturated fatty acids at different glucose concentrations on human beta-cell turnover and secretory function. Exposure of cultured human islets to saturated fatty acid and/or to an elevated glucose concentration for 4 days increased beta-cell DNA fragmentation and decreased beta-cell proliferation. In contrast, the monounsaturated… CONTINUE READING
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