• DOI:10.2337/DIABETES.52.3.726
Corpus ID: 1466959

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function.

@article{Maedler2003MonounsaturatedFA,
  title={Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function.},
  author={K. Maedler and J. Oberholzer and P. Bucher and G. Spinas and M. Donath},
  journal={Diabetes},
  year={2003},
  volume={52 3},
  pages={
          726-33
        }
}

K. Maedler, J. Oberholzer, +2 authors M. Donath

Published 2003

Biology, Medicine

Diabetes

Glucotoxicity and lipotoxicity contribute to the impaired beta-cell function observed in type 2 diabetes. Here we examine the effect of saturated and monounsaturated fatty acids at different glucose concentrations on human beta-cell turnover and secretory function. Exposure of cultured human islets to saturated fatty acid and/or to an elevated glucose concentration for 4 days increased beta-cell DNA fragmentation and decreased beta-cell proliferation. In contrast, the monounsaturated… CONTINUE READING

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