Monotreme IGF2 expression and ancestral origin of genomic imprinting.

  title={Monotreme IGF2 expression and ancestral origin of genomic imprinting.},
  author={James K. Killian and Catherine S. Nolan and N. F. Stewart and Barry L. Munday and Niels A. Andersen and Stewart Nicol and Randy L. Jirtle},
  journal={The Journal of experimental zoology},
  volume={291 2},
IGF2 (insulin-like growth factor 2) and M6P/IGF2R (mannose 6-phosphate/insulin-like growth factor 2 receptor) are imprinted in marsupials and eutherians but not in birds. These results along with the absence of M6P/IGF2R imprinting in the egg-laying monotremes indicate that the parental imprinting of fetal growth-regulatory genes may be unique to viviparous mammals. In this investigation, we have cloned IGF2 from two monotreme mammals, the platypus and echidna, to further investigate the origin… CONTINUE READING
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