Monotopic enzymes and lipid bilayers: a comparative study.

@article{Fowler2007MonotopicEA,
  title={Monotopic enzymes and lipid bilayers: a comparative study.},
  author={Philip W Fowler and Kia Balali-Mood and Sundeep Singh Deol and Peter V. Coveney and Mark S. P. Sansom},
  journal={Biochemistry},
  year={2007},
  volume={46 11},
  pages={
          3108-15
        }
}
Monotopic proteins make up a class of membrane proteins that bind tightly to, but do not span, cell membranes. We examine and compare how two monotopic proteins, monoamine oxidase B (MAO-B) and cyclooxygenase-2 (COX-2), interact with a phospholipid bilayer using molecular dynamics simulations. Both enzymes form between three and seven hydrogen bonds with the bilayer in our simulations with basic side chains accounting for the majority of these interactions. By analyzing lipid order parameters… CONTINUE READING

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