Monotherapy with darunavir/ritonavir or lopinavir/ritonavir versus standard antiretroviral therapy: a randomized clinical trial (2pm Study).

Abstract

In a multicentre, open-label, clinical trial, 43 patients virologically suppressed while receiving a standard triple antiretroviral therapy were randomized (1:1:1) to switch to monotherapy with darunavir/ritonavir (DRV/r-MT arm), monotherapy with lopinavir/ritonavir (LPV/r-MT arm) or to continue on the ongoing regimen (cART arm). The proportion (95% CI) of patients with virological success (Snapshot analysis) at week 48 was 73% (48%-90%) in the DRV/r-MT arm, 69% (42%-88%) in the LPV/r-MT arm and 87% (61%-98%) in the cART arm. Virological failure was detected in only one patient receiving LPV/r-MT. The LPV/r-MT arm showed a modest worsening in lipid profile.

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Cite this paper

@article{Gianotti2016MonotherapyWD, title={Monotherapy with darunavir/ritonavir or lopinavir/ritonavir versus standard antiretroviral therapy: a randomized clinical trial (2pm Study).}, author={Nicola Gianotti and Laura Galli and Renato Maserati and Laura Sighinolfi and Diego Ripamonti and Loredana Palvarini and Sergio lo Caputo and Emanuele Foc{\'a} and Benedetto Maurizio Celesia and Franco Baldelli and Gaetana Sterrantino and Adriano Lazzarin}, journal={The new microbiologica}, year={2016}, volume={39 4}, pages={290-294} }