Monotherapy rapamycin allows an increase of CD4 CD25 FoxP3 T cells in renal recipients.

Abstract

CD4(+) CD25(bright+) FoxP3(+) regulatory T cells (Tregs) may control donor-specific allogeneic responses in kidney transplant recipients. Recent evidence demonstrated that three phenotypical Treg-subsets, naive (CCR7(+)CD45RO(-)), central-memory (CCR7(+)CD45RO(+)) and effector-memory (CCR7(-)CD45RO(+)), are essential for the development and function of… (More)
DOI: 10.1111/j.1432-2277.2009.00890.x

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