Monoterpenoids induce agonist-specific desensitization of transient receptor potential vanilloid-3 (TRPV3) ion channels.

Abstract

PURPOSE Transient receptor potential vanilloid-3 (TRPV3) is a thermo-sensitive ion channel expressed in skin keratinocytes and in a variety of neural cells. It is activated by warmth as well as monoterpenoids including camphor, menthol, dihydrocarveol and 1,8-cineol. TRPV3 is described as a putative nociceptor and previous studies revealed sensitization of… (More)

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Cite this paper

@article{Sherkheli2009MonoterpenoidsIA, title={Monoterpenoids induce agonist-specific desensitization of transient receptor potential vanilloid-3 (TRPV3) ion channels.}, author={Muhammad Azhar Sherkheli and Heike Benecke and Julia Franca Doerner and Olaf Kletke and Angela K Vogt-Eisele and Guenter Gisselmann and Hanns Hatt}, journal={Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques}, year={2009}, volume={12 1}, pages={116-28} }