Monoterpenoid indole alkaloids from the bark of Melodinus henryi.

@article{He2019MonoterpenoidIA,
  title={Monoterpenoid indole alkaloids from the bark of Melodinus henryi.},
  author={Juan He and Fa-Lei Zhang and Zheng-Hui Li and Hui-Xiang Yang and Qian Shao and Tao Feng and Jikai Liu},
  journal={Fitoterapia},
  year={2019},
  pages={
          104354
        }
}
7 Citations
Monoterpenoid Quinoline Alkaloids from Stems and Leaves of Melodinus tenuicaudatus
Two previously undescribed monoterpenoid quinoline alkaloids, namely melotenucadines A and B, together with four known analogs, were characterized from the stems and leaves of Melodinus
Melodinines Y1–Y4, four monoterpene indole alkaloids from Melodinus henryi
Melodinines Y1–Y4 (1–4), four undescribed alkaloids were isolated from Melodinus henryi. Their structures were elucidated by extensive NMR, mass spectroscopic analyses, theoretical NMR and electronic
Taccachatrones A-G, Highly Oxidized Steroids from the Rhizomes of Tacca chantrierii and Their Cytotoxicity Assessment.
TLDR
Seven highly oxidized steroids, taccachatrones A-G (1-7), together with four known taccalonolides (8-11), were characterized from the rhizomes of Tacca chantrieri, indicating that the presence of a lactone moiety, as well as a double bond between C-22 and C-23, might play key roles in mediating their cytotoxicity.
Illudane Sesquiterpenoids from Edible Mushroom Agrocybe salicacola and Their Bioactivities
TLDR
A. salicacola is rich in illudin derivatives with potential bioactivity prospects, which would make A. saliacola a good material of medicine and food homology.
Acute and Sub-Acute Toxicological Evaluations of Bioactive Alkaloidal Extract from Melodinus henryi and Their Main Chemical Constituents
TLDR
Melodinus henryi is a good source of terpenoid indole alkaloids, and traditionally used as a folk medicine in the treatment of meningitis and fracture, but its anti-inflammatory and immunosuppressive activities, safety evaluations and chemical profiles have been illustrated.
Indole alkaloids with potential anticancer activity.
  • Dan Xu, Zhi Xu
  • Chemistry, Biology
    Current topics in medicinal chemistry
  • 2020
TLDR
This review emphasizes the recent development of indole alkaloids as potential anticancer agents, their structure-activity relationship and mechanisms of action covering the articles published from 2015 to 2020.

References

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Cytotoxic indole alkaloids from Melodinus tenuicaudatus.
TLDR
Alkaloids 1, 3, and 4 and the known compound 11-methoxytabersonine (8) exhibited inhibitory effects, with IC(50) values comparable to those of cisplatin and vinorelbine.
Melodinines A-G, monoterpenoid indole alkaloids from Melodinus henryi.
Nineteen monoterpenoid indole alkaloids including seven new ones, melodinines A-G (1-7), were isolated from Melodinus henryi. The structures of the new compounds were elucidated using spectroscopic
Melohenines A and B, two unprecedented alkaloids from Melodinus henryi.
A phytochemical study on Melodinus henryi has led to the isolation of two novel alkaloids, melohenines A (1), a monoterpenoid indole alkaloid with additional skeletal carbons arranged compactly in
Melotenine A, a cytotoxic monoterpenoid indole alkaloid from Melodinus tenuicaudatus.
TLDR
The structure was elucidated by means of spectroscopic methods and further confirmed by the single-crystal X-ray diffraction analysis and a possible biogenesis was also proposed.
Melodinines M-U, cytotoxic alkaloids from Melodinus suaveolens.
TLDR
Nine new alkaloid structures, melodinines M-U (1-9), and 11 known alkaloids were isolated from Melodinus suaveolens by extensive NMR and mass spectroscopic analyses and comparison to known compounds.
Monoterpenoid indole alkaloids from Alstonia yunnanensis.
TLDR
Eight new monoterpenoid indole alkaloids, alstoyunines A-H (1-8), along with 17 known analogues, were isolated from Alstonia yunnanensis and showed weak cytotoxicity against the human myeloid leukemia HL-60 and hepatocellular carcinoma cell lines.
Aspidosperma-type Alkaloids from Melodinus Suaveolens
TLDR
Three new aspidosperma-type alkaloids were isolated from the twigs and leaves of Melodinus suaveolens, and the structures of the new compounds were elucidated by using spectroscopic methods, and circular dichroism experiments.
Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi.
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