Monoterpenic aldehydes as potential anti-Leishmania agents: activity of Cymbopogon citratus and citral on L. infantum, L. tropica and L. major.

@article{Machado2012MonoterpenicAA,
  title={Monoterpenic aldehydes as potential anti-Leishmania agents: activity of Cymbopogon citratus and citral on L. infantum, L. tropica and L. major.},
  author={Marisa Machado and Pedro Pires and Augusto M. Dinis and Manuel Santos-Rosa and Vera Alves and Luis Salgueiro and Carlos Cavaleiro and Marcelo C Sousa},
  journal={Experimental parasitology},
  year={2012},
  volume={130 3},
  pages={223-31}
}
In order to contribute for the search of new drugs for leishmaniasis, we study the susceptibility of Leishmania infantum, Leishmania tropica and Leishmania major to Cymbopogon citratus essential oil and major compounds, mrycene and citral. C. citratus and citral were the most active inhibiting L. infantum, L. tropica and L. major growth at IC(50) concentrations ranging from 25 to 52 μg/ml and from 34 to 42 μg/ml, respectively. L. infantum promastigotes exposed to essential oil and citral… CONTINUE READING