Monoterpene Glycoside ESK246 from Pittosporum Targets LAT3 Amino Acid Transport and Prostate Cancer Cell Growth

@article{Wang2014MonoterpeneGE,
  title={Monoterpene Glycoside ESK246 from Pittosporum Targets LAT3 Amino Acid Transport and Prostate Cancer Cell Growth},
  author={Qian Wang and Tanja Grkovic and Josep Font and Sarah Bonham and Rebecca H. Pouwer and Charles G. Bailey and Anne Marie Mor{\'a}n and Renae M. Ryan and John E. J. Rasko and Mika Jormakka and Ronald J. Quinn and Jeff Holst},
  journal={ACS Chemical Biology},
  year={2014},
  volume={9},
  pages={1369 - 1376}
}
The l-type amino acid transporter (LAT) family consists of four members (LAT1–4) that mediate uptake of neutral amino acids including leucine. Leucine is not only important as a building block for proteins, but plays a critical role in mTORC1 signaling leading to protein translation. As such, LAT family members are commonly upregulated in cancer in order to fuel increased protein translation and cell growth. To identify potential LAT-specific inhibitors, we established a function-based high… Expand
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It is proposed that LAT1 is involved in cellular amino acid uptake, whereas LAT2 plays a role in epithelial amino acid (re)absorption in vertebrate gpaATs. Expand
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TLDR
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