Monosomy of chromosome 3 and an inflammatory phenotype occur together in uveal melanoma.

@article{Maat2008MonosomyOC,
  title={Monosomy of chromosome 3 and an inflammatory phenotype occur together in uveal melanoma.},
  author={Willem Maat and Long V. Ly and Ekaterina S Jordanova and Didi de Wolff-Rouendaal and Nicoline E Schalij-Delfos and Martine J. Jager},
  journal={Investigative ophthalmology & visual science},
  year={2008},
  volume={49 2},
  pages={505-10}
}
PURPOSE In uveal melanoma, different predictors of poor prognosis have been identified, including monosomy of chromosome 3, HLA expression, and the presence of infiltrating leukocytes and macrophages. Each of these parameters can be used to differentiate prognostically the favorable tumors from the unfavorable ones, and thus the hypothesis for the present study was that they are related, and that monosomy of chromosome 3 occurs in the same tumors as the unfavorable inflammatory phenotype… CONTINUE READING

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