Monosomy 7 in patients with aplastic anemia and paroxysmal nocturnal hemoglobinuria with evolution into acute myeloid leukemia.

@article{Auewarakul2004Monosomy7I,
  title={Monosomy 7 in patients with aplastic anemia and paroxysmal nocturnal hemoglobinuria with evolution into acute myeloid leukemia.},
  author={Chirayu Udomsakdi Auewarakul and Chintana Tocharoentanaphol and Wanchai Wanachiwanawin and Surapol Issaragrisil},
  journal={Journal of the Medical Association of Thailand = Chotmaihet thangphaet},
  year={2004},
  volume={87 6},
  pages={717-21}
}
We report two cases of Thai patients with aplastic anemia/paroxysmal nocturnal hemoglobinuria (AA/PNH) who subsequently developed acute myeloid leukemia (AML) at their terminal phase. Monosomy 7 was demonstrated upon karyotypic analysis of bone marrow in both cases at the time leukemia developed The first patient was a 25-year-old man diagnosed with AA at… CONTINUE READING