Monosomy 7 associated with pediatric acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS): successful management by allogeneic hematopoietic stem cell transplant (HSCT)

@article{TrobaughLotrario2005Monosomy7A,
  title={Monosomy 7 associated with pediatric acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS): successful management by allogeneic hematopoietic stem cell transplant (HSCT)},
  author={Angela D Trobaugh-Lotrario and Morris Kletzel and Ralph R Quinones and Loris McGavran and Maria A. Proytcheva and Stephen P Hunger and Janet Malcolm and Deborah Schissel and Elaine Hild and Roger H. Giller},
  journal={Bone Marrow Transplantation},
  year={2005},
  volume={35},
  pages={143-149}
}
Summary:Pediatric acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) with monosomy 7 is associated with poor disease-free survival when treated by conventional chemotherapy, immunosuppression or supportive measures. Hematopoietic stem cell transplant (HSCT) may improve outcomes; however, data to support this are limited. To better understand the curative potential of HSCT in these patients, all cases of AML and MDS with monosomy 7 treated by two transplant programs (1992 to present… CONTINUE READING

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