Monosomy 20 as a pointer to dicentric (9;20) in acute lymphoblastic leukemia

  title={Monosomy 20 as a pointer to dicentric (9;20) in acute lymphoblastic leukemia},
  author={R W Clark and S A Byatt and C Bennett and M Bra and Mary Martineau and A V Moorman and Karen Roberts and L M Secker-Walker and S G Richards and O. B. Eden and A I Goldstone and C M Harrison},
Twenty new cases of acute lymphoblastic leukemia (ALL) with the dicentric chromosome dic(9;20)(p1113;q11) are presented. This chromosomal abnormality is difficult to identify from G-banding alone. It masquerades as monosomy 20 and is only accurately identified by fluorescence in situ hybridization (FISH). Monosomy 20 was found in 59/2790 patients with successful karyotypes entered to the Leukaemia Research Fund/UK Cancer Cytogenetics Group Karyotype Database in ALL (LRF/UKCCG Karyotype Database… CONTINUE READING


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